NDC80 and KLC3

Data Source:
BioGRID (two hybrid)

		NDC80	KLC3
Description		NDC80 kinetochore complex component	kinesin light chain 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex	Cytoplasm Kinesin Complex Microtubule Motile Cilium Ciliary Rootlet Neuron Projection
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Microtubule Binding Kinesin Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centrosome Duplication Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore	Axo-dendritic Transport
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971)
Interacting Genes		64 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CENPH CEP63 CKAP5 EPS15L1 EXOC8 FAM9C GOLGA2 HAUS1 HGS HIP1R IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PPP1R13B PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 THOC7 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT	42 interacting genes: ABI3 ATP23 BBS5 BICDL2 CBY2 CCNH CENPP CEP57L1 CROCC CT55 DTX2 GEM IHO1 IMP3 KDM1A KIF5A KIF5B KIF5C KLHL21 KRT13 KRT15 MBIP NDC80 NECAB2 NEFL PCBD2 PDE4DIP QARS1 SMARCB1 SNAP47 STX11 TCF4 TSNAX USHBP1 VPS52 WAC WASHC1 YWHAG YWHAH YWHAQ ZNF417 ZNF572
Entrez ID		10403	147700
HPRD ID		06277	03212
Ensembl ID		ENSG00000080986	ENSG00000104892
Uniprot IDs		A8K031 O14777	A0A024R0V3 Q6P597
PDB IDs		2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?