TUBB4B and TINF2

Data Source:
BioGRID (two hybrid)

		TUBB4B	TINF2
Description		tubulin beta 4B class IVb	TERF1 interacting nuclear factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Azurophil Granule Lumen Extracellular Exosome Extracellular Vesicle	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex
	Molecular Function	Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding MHC Class I Protein Binding Unfolded Protein Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Natural Killer Cell Mediated Cytotoxicity Neutrophil Degranulation Ciliary Basal Body-plasma Membrane Docking	Negative Regulation Of Protein ADP-ribosylation Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs		Albendazole Mebendazole Epothilone D Patupilone Oxibendazole CYT997 Phenethyl Isothiocyanate
Diseases			Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS			Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		19 interacting genes: ACD CDKN2A DAPK1 DLEU1 DLST ENOX2 LINC01554 NEAT1 POT1 PSME1 PTEN PTPRF SCG2 SOCS6 SOCS7 SUMO2 TERF1 TINF2 TUBG1	89 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		10383	26277
HPRD ID		04043	16056
Ensembl ID		ENSG00000188229	ENSG00000092330
Uniprot IDs		P68371	Q9BSI4
PDB IDs			3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?
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