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TINF2 and ANXA5
Data Source:
BioGRID
(two hybrid)
TINF2
ANXA5
Description
TERF1 interacting nuclear factor 2
annexin A5
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleoplasm
Perinucleolar Chromocenter
Nuclear Matrix
Nuclear Body
Shelterin Complex
Extracellular Region
Cytoplasm
Cytosol
Focal Adhesion
Membrane
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
DNA Binding
Protein Binding
Telomeric DNA Binding
Phospholipase Inhibitor Activity
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Calcium-dependent Phospholipid Binding
Biological Process
Negative Regulation Of Protein ADP-ribosylation
Telomere Capping
Telomere Assembly
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Epithelial Cell Proliferation
Protein Localization To Chromosome, Telomeric Region
Regulation Of Telomere Maintenance Via Telomere Lengthening
Platelet Degranulation
Signal Transduction
Blood Coagulation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Catalytic Activity
Negative Regulation Of Coagulation
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Platelet degranulation
Drugs
Fluocinolone acetonide
L-Alpha-Glycerophosphorylserine
L-thioproline
K201 free base
sn-glycero-3-phosphoethanolamine
1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
N,O6-Disulfo-Glucosamine
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
Copper
Diseases
Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS
Leukocyte telomere length (
31171785
)
Platelet count (
29403010
)
Age at smoking initiation in chronic obstructive pulmonary disease (
21685187
)
Age-related cognitive decline (language) (slope of z-scores) (
30954325
)
Resting-state electroencephalogram vigilance (
29703947
)
Interacting Genes
89 interacting genes:
ACD
ACOT7
ACTB
ADA
AFAP1L2
AIPL1
AK1
ANKMY2
ANXA4
ANXA5
ANXA8L1
APOBEC3F
APPL2
ARHGDIA
ARID3B
BAG3
BIN2
CALD1
CCDC43
CCDC9
CKB
CLK3
CPNE3
CRYGS
CTTN
DBN1
DCX
DHFR2
DPP3
EEF1D
EIF4B
ENO2
FAM131B
FERMT3
FKBP6
GAPDH
GNMT
HNMT
HOXA3
HSP90AB1
IPO5
KCTD17
LASP1
LDHA
LGALSL
LTA4H
MAP2K3
MTNR1B
NCDN
NOL3
NUDC
NUDCD2
OR2H1
PAGE2
PAK1IP1
PEX5
PFKP
PGM1
PGM2
PHPT1
PKM
PPP1R2
PPP6R3
PRKCB
REM2
RGS14
RPSA
SARS1
SCRN2
SIAH2
STUB1
SULT1C2
TAGLN
TBL1X
TERF1
TERF2
TOMM34
TPP1
TRIM15
TRIM16
TRIP10
TUBB
TUBB4B
TXNDC17
UCHL1
VIPR1
YWHAG
ZFP36L1
ZNF790
19 interacting genes:
ACTG1
APP
COL10A1
COL2A1
EED
EIF4G1
FDFT1
GSC2
IFNGR2
ITGB5
KDR
LAMC3
LINC01554
PPP2R1B
SUPT4H1
TERF1
TERF2
TERF2IP
TINF2
Entrez ID
26277
308
HPRD ID
16056
00568
Ensembl ID
ENSG00000092330
ENSG00000164111
Uniprot IDs
Q9BSI4
P08758
V9HWE0
PDB IDs
3BQO
3BU8
5XYF
1ANW
1ANX
1AVH
1AVR
1HAK
1HVD
1HVE
1HVF
1HVG
1SAV
2XO2
2XO3
6K22
6K25
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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