AKR1A1 and HTR6

Data Source:
BioGRID (two hybrid)

		AKR1A1	HTR6
Description		aldo-keto reductase family 1 member A1	5-hydroxytryptamine receptor 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Apical Plasma Membrane Synapse Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Cilium Dendrite Synapse
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Retinol Dehydrogenase Activity Protein Binding Electron Transfer Activity Allyl-alcohol Dehydrogenase Activity L-glucuronate Reductase Activity Glucuronolactone Reductase Activity	Histamine Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity
	Biological Process	Glucose Metabolic Process Cellular Aldehyde Metabolic Process Glucuronate Catabolic Process To Xylulose 5-phosphate L-ascorbic Acid Biosynthetic Process Electron Transport Chain D-glucuronate Catabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Glutathione Derivative Biosynthetic Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Cerebral Cortex Cell Migration Positive Regulation Of TOR Signaling G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Glutathione conjugation Formation of xylulose-5-phosphate	Serotonin receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Tolrestat Nicotinamide adenine dinucleotide phosphate Copper	Ziprasidone Amitriptyline Olanzapine Clozapine Loxapine Imipramine Chlorpromazine Haloperidol Amoxapine Paroxetine Cyclobenzaprine Ergoloid mesylate Doxepin Quetiapine Aripiprazole Chlorprothixene Dimethyltryptamine Lysergic acid diethylamide Iloperidone SGS518 PRX-07034 SUVN-502 Sertindole Mianserin Asenapine Zotepine Setiptiline Dihydroergocornine Gilteritinib Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 32888494 27863252) Pulse pressure ( 30224653 30578418) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Chronotype ( 26955885 27494321) Morning person ( 30696823) Morning vs. evening chronotype ( 26955885 27494321)
Interacting Genes		4 interacting genes: EXOSC4 HTR6 TERF1 TERF2IP	31 interacting genes: ABCA2 ACTB AIP AKR1A1 AP2M1 AP4S1 ATXN10 CHN1 CMSS1 COPS5 DDRGK1 DHRS1 EIF4A3 FYN GNAQ GNAS HDGFL2 IDS MAP1B NF1 NRXN3 PARP8 RUNDC3A SCHIP1 SLC6A1 SRRT SYT5 THY1 TMEM98 TTYH1 UQCRFS1
Entrez ID		10327	3362
HPRD ID		00069	03066
Ensembl ID		ENSG00000117448	ENSG00000158748
Uniprot IDs		P14550 V9HWI0	P50406
PDB IDs		2ALR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?