DLST and OGDH

Data Source:
HPRD (in vitro)

		DLST	OGDH
Description		dihydrolipoamide S-succinyltransferase	oxoglutarate dehydrogenase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Centriolar Satellite Oxoglutarate Dehydrogenase Complex	Nucleus Mitochondrion Mitochondrial Matrix Mitochondrial Membrane Oxoglutarate Dehydrogenase Complex
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity, Transferring Acyl Groups	Oxoglutarate Dehydrogenase (succinyl-transferring) Activity Protein Binding Thiamine Pyrophosphate Binding Metal Ion Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process Protein Phosphopantetheinylation L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Histone Succinylation	Generation Of Precursor Metabolites And Energy Glycolytic Process Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process Histone Succinylation
Pathways		Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)	Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)
Drugs			NADH Valproic acid Xanthinol
Diseases			Diseases of the tricarboxylic acid cycle, including: Fumarase (FH) deficiency; Succinate dehydrogenase (SDH) deficiency; Alpha-ketoglutarate dehydrogenase (AKGDH) deficiency
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Eosinophil counts ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)	Low density lipoprotein cholesterol levels ( 32154731) Lung cancer in never smokers ( 28604730) Systolic blood pressure change trajectories ( 27980656)
Interacting Genes		16 interacting genes: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UBE2D2 UMPS ZBTB16 ZHX1	5 interacting genes: ANXA2 DLD DLST HSD17B10 PLSCR1
Entrez ID		1743	4967
HPRD ID		00520	08938
Ensembl ID		ENSG00000119689	ENSG00000105953
Uniprot IDs		A0A024R6C9 B7Z6J1 P36957	A0A140VJQ5 B4E3E9 E9PCR7 Q02218
PDB IDs		6H05	3ERY
Enriched GO Terms of Interacting Partners?
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