SPRY2 and MAPKBP1

Data Source:
BioGRID (two hybrid)

		SPRY2	MAPKBP1
Description		sprouty RTK signaling antagonist 2	mitogen-activated protein kinase binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Ruffle Membrane Microtubule End	Nucleoplasm Nucleolus Cytoplasm Mitotic Spindle Pole
	Molecular Function	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity	Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Projection Organization Negative Regulation Of Protein Ubiquitination Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of GTPase Activity Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Cell Fate Commitment Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Lung Growth Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Interleukin-8 Production Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Bacterium
Pathways		Spry regulation of FGF signaling EGFR downregulation
Drugs
Diseases
GWAS		Adiposity ( 21706003) Adventurousness ( 30643258) Body fat percentage ( 26833246) Central corneal thickness ( 32528159) Cleft lip with or without cleft palate ( 28054174) Diastolic blood pressure ( 30224653) Fasting blood insulin (BMI interaction) ( 22581228) General risk tolerance (MTAG) ( 30643258) Height ( 25282103 31562340) Insulin-related traits (multivariate analysis) ( 32002517) Lactose tolerance test ( 31791255) Leisure-time exercise behaviour (age-stratified) ( 30102679) Medication use (drugs used in diabetes) ( 31015401) Methadone dose in opioid dependence ( 28115739) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 20023658 22863734 28054174) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Sleep duration ( 25469926) Thrombocytopenia in coronary artery bypass surgery ( 30103242) Type 2 diabetes ( 22885922 24509480 30054458 20862305 29358691 30297969 26818947 31118516 32499647 30718926 28869590) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Diastolic blood pressure ( 27841878) Urinary albumin excretion ( 30220432) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		105 interacting genes: ADAMTSL4 AQP1 ATRIP BAG3 BRAF CATSPER1 CBL CBLB CBLC CHRD CHRNG CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 EIF4E2 FAIM FAM219A FBN1 FBXO7 FRS3 GNE GP9 GPRIN2 GRAP2 GRB2 GRN HEXIM2 HNRNPLL HOXA1 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1A LCE1B LCE1C LCE1F LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MB21D2 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 OTX1 PACSIN3 PLSCR1 PRKAB2 PRKCD PRKD1 PTGER3 PTPN11 RAF1 RTF2 RUNX1T1 SDHB SEMA5B SH3KBP1 SHFL SIAH2 SPRY1 STK16 TCAF1 TMEM14B TNS2 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587	62 interacting genes: ADAM12 ADAMTSL4 ALG13 APTX CTDSP1 CYSRT1 FOXN1 GLRX3 HOXA1 KEAP1 KPRP KRT31 KRT34 KRT35 KRT38 KRT40 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP13-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 MAPK10 MAPK8 MAPK9 MDFI MEOX2 METTL15 MYOG NBPF19 NOTCH2NLA PLA2G10 PLSCR3 RBCK1 RGS20 SIAH1 SPRY2 SPRY3 TCF12 TCF4 TEKT5 TEX11 TRIM27 TRIM42 TRIP6 YPEL5 ZNF34
Entrez ID		10253	23005
HPRD ID		03916	17465
Ensembl ID		ENSG00000136158	ENSG00000137802
Uniprot IDs		O43597	O60336
PDB IDs		3BUM 3OB1 5HKY 5HKZ 5HL0
Enriched GO Terms of Interacting Partners?
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