MPHOSPH6 and THOP1

Data Source:
HPRD (two hybrid)

		MPHOSPH6	THOP1
Description		M-phase phosphoprotein 6	thimet oligopeptidase 1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol	Mitochondrial Intermembrane Space Cytosol
	Molecular Function	RNA Binding Protein Binding	Metalloendopeptidase Activity Protein Binding Peptide Binding Metal Ion Binding
	Biological Process	Maturation Of 5.8S RRNA RRNA Processing	Protein Polyubiquitination Proteolysis Peptide Metabolic Process
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Seasonality and depression ( 30217971)	Low density lipoprotein cholesterol levels ( 32154731) Platelet count ( 32888494) Plateletcrit ( 32888494) Total cholesterol levels ( 28334899)
Interacting Genes		32 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC1 EXOSC10 EXOSC3 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1	9 interacting genes: AGTR1 CALM1 EPN2 LINC01554 MPHOSPH6 PALS2 PRKACA STK11 TRAF2
Entrez ID		10200	7064
HPRD ID		16111	03072
Ensembl ID		ENSG00000135698	ENSG00000172009
Uniprot IDs		H3BNT4 Q99547	P52888
PDB IDs		6D6Q 6D6R 6H25	1S4B 2O36
Enriched GO Terms of Interacting Partners?
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