MPHOSPH6 and HSBP1

Data Source:
HPRD (in vitro)

		MPHOSPH6	HSBP1
Description		M-phase phosphoprotein 6	heat shock factor binding protein 1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol	Nucleus Nucleoplasm Cytosol Cytoskeleton
	Molecular Function	RNA Binding Protein Binding	Transcription Corepressor Activity Protein Binding Identical Protein Binding
	Biological Process	Maturation Of 5.8S RRNA RRNA Processing	Negative Regulation Of Transcription By RNA Polymerase II Muscle Contraction Endodermal Cell Differentiation Cellular Heat Acclimation Regulation Of Cellular Response To Heat
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	HSF1 activation Attenuation phase HSF1-dependent transactivation
Drugs
Diseases
GWAS		Leukocyte telomere length ( 32109421 31171785) Lung adenocarcinoma ( 28604730) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Seasonality and depression ( 30217971)	Lead levels ( 26025379) Metabolite levels ( 23823483) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872)
Interacting Genes		32 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC1 EXOSC10 EXOSC3 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1	21 interacting genes: BLOC1S5 BRK1 CCHCR1 CYSRT1 GORASP2 HSF1 HSPA1A KIAA1217 KIFC3 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 LNX1 MPP7 NOTCH2NLA SDCBP SDCBP2 WASHC1 WASHC3 ZBTB25
Entrez ID		10200	3281
HPRD ID		16111	05185
Ensembl ID		ENSG00000135698	ENSG00000230989
Uniprot IDs		H3BNT4 Q99547	O75506
PDB IDs		6D6Q 6D6R 6H25	3CI9
Enriched GO Terms of Interacting Partners?
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