KPRP and BTC

Data Source:
BioGRID (two hybrid)

		KPRP	BTC
Description		keratinocyte proline rich protein	betacellulin
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane
	Molecular Function	Protein Binding	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process		MAPK Cascade Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Urine Volume ERBB2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Membrane Organization Regulation Of Cell Motility
Pathways			Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Asthma ( 31619474) Psoriasis ( 25854761)	Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561) Diverticular disease ( 30177863) Electroencephalogram traits ( 25387704) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560)
Interacting Genes		108 interacting genes: AKAP8L ANKS1A ATG9A BTC C19orf54 CATSPER1 CCDC57 CES1 CKS1B CLCNKA CNFN CNNM3 COL8A1 CREB5 CYSRT1 DARS1-AS1 DMRT3 DYRK1A EIF3E ESR2 FAM221B FAM72B FBXO17 FCHO1 FHL2 FHL3 FRS3 GNE GRAP2 GRB2 GUCD1 HCK HEXIM2 HNRNPF HOXA1 HOXC8 HSD3B7 ITGB4 ITIH6 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP12-3 KRTAP13-2 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-2 KRTAP19-5 KRTAP19-6 KRTAP19-7 KRTAP3-2 KRTAP4-2 KRTAP4-5 KRTAP5-3 KRTAP5-7 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 LCE3C LCE3D LCE3E LIMS1 LMO2 LNX1 MAPKBP1 MEOX2 MGAT5B MIIP MLH1 NBPF19 NCK2 NID2 NOTCH2NLA NPBWR2 NR4A3 NTN4 NUFIP2 OTX1 PDGFRB PHLDA1 PLA2G10 PLSCR4 POU4F2 PPIL1 PPP1R32 RANBP3 RBP3 RGL2 RNF38 SEMA3B SH3KBP1 SLC15A2 SPRED2 SPRY1 SPRY3 STK16 TEKT4 TFAP2D TNS2 TRIM42 TRIP6 UBASH3A UBASH3B VGLL3 VWC2 ZNF587	11 interacting genes: DNAJC5 EGFR ERBB2 ERBB4 GMPPA KPRP KRT31 KRTAP1-3 MMP9 SGTA SGTB
Entrez ID		448834	685
HPRD ID		18838	02643
Ensembl ID		ENSG00000203786	ENSG00000174808
Uniprot IDs		Q5T749	A0A0S2Z3I5 A0A0S2Z437 P35070
PDB IDs			1IOX 1IP0
Enriched GO Terms of Interacting Partners?
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