NR2E3 and DHX30

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		NR2E3	DHX30
Description		nuclear receptor subfamily 2 group E member 3	DExH-box helicase 30
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex	Intracellular Anatomical Structure Cytoplasm Mitochondrion Cytosol Ribonucleoprotein Granule Mitochondrial Nucleoid
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	Chromatin Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Visual Perception Phototransduction Negative Regulation Of Cell Population Proliferation Cell Differentiation Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development Retina Development In Camera-type Eye	Central Nervous System Development Mitochondrial Large Ribosomal Subunit Assembly
Pathways
Drugs
Diseases		Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Retinitis pigmentosa (RP)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Macular thickness ( 30535121) Metabolite levels (HVA/MHPG ratio) ( 23319000) Red blood cell count ( 32888494)
Interacting Genes		29 interacting genes: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 NRL POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 WDR5 ZNF232	17 interacting genes: CDK9 DHX58 DUX4 HDAC1 HDAC3 HNRNPD MYBBP1A NCOR1 NEDD4 NR2E3 OAS3 RBBP4 RBBP7 RBL1 SIN3A SKIL TBL3
Entrez ID		10002	22907
HPRD ID		05132	13142
Ensembl ID		ENSG00000278570	ENSG00000132153
Uniprot IDs		F1D8Q9 Q9Y5X4	H7BXY3 Q7L2E3
PDB IDs		4LOG	2DB2
Enriched GO Terms of Interacting Partners?
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