NR2E3 and NRL

Data Source:
BioGRID (fluorescent resonance energy transfer, fluorescent resonance energy transfer)

		NR2E3	NRL
Description		nuclear receptor subfamily 2 group E member 3	neural retina leucine zipper
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Leucine Zipper Domain Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Visual Perception Phototransduction Negative Regulation Of Cell Population Proliferation Cell Differentiation Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development Retina Development In Camera-type Eye	Regulation Of Transcription By RNA Polymerase II Visual Perception Positive Regulation Of Transcription By RNA Polymerase II Retinal Rod Cell Development Response To Stimulus
Pathways
Drugs
Diseases		Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Retinitis pigmentosa (RP)	Retinitis pigmentosa (RP)
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Macular thickness ( 30535121) Metabolite levels (HVA/MHPG ratio) ( 23319000) Red blood cell count ( 32888494)	Attention deficit hyperactivity disorder symptom score ( 27663945) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		29 interacting genes: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 NRL POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 WDR5 ZNF232	6 interacting genes: CRX EDF1 FIZ1 MAPK1 MAPK14 NR2E3
Entrez ID		10002	4901
HPRD ID		05132	08875
Ensembl ID		ENSG00000278570	ENSG00000129535
Uniprot IDs		F1D8Q9 Q9Y5X4	P54845
PDB IDs		4LOG
Enriched GO Terms of Interacting Partners?
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