KMT2E

Description		lysine methyltransferase 2E (inactive)
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Neutrophil Mediated Immunity DNA Methylation Cell Cycle Arrest Erythrocyte Differentiation Histone Lysine Methylation Neutrophil Activation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Novel Interacting Genes		8 novel interacting genes: ALKBH4 CYP2C18 FIS1 IFT22 MAPRE2 NFE4 TRAPPC14 ZCWPW1
Interacting Genes		4 interacting genes: ASH2L ATP13A1 CDK1 LAMTOR5
Entrez ID		55904
HPRD ID		10528
Ensembl ID		ENSG00000005483
Uniprot IDs		Q8IZD2
PDB IDs		2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
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