KMT2E and TRAPPC14

Data Source:
BioGRID (two hybrid)

		KMT2E	TRAPPC14
Description		lysine methyltransferase 2E (inactive)	trafficking protein particle complex subunit 14
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin	Plasma Membrane Midbody Centriolar Satellite Intracellular Membrane-bounded Organelle Mitotic Spindle TRAPPII Protein Complex
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding	Protein Binding Alpha-tubulin Binding
	Biological Process	Neutrophil Mediated Immunity DNA Methylation Cell Cycle Arrest Erythrocyte Differentiation Histone Lysine Methylation Neutrophil Activation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation	Regulation Of Cell Population Proliferation Cilium Assembly
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)
Interacting Genes		4 interacting genes: ASH2L ATP13A1 CDK1 LAMTOR5	8 interacting genes: AGXT CYSRT1 KRTAP6-1 NBPF19 NOTCH2NLA TGM1 TMEM50A VWC2
Entrez ID		55904	55262
HPRD ID		10528	07716
Ensembl ID		ENSG00000005483	ENSG00000146826
Uniprot IDs		Q8IZD2	B3KNS5 Q8WVR3
PDB IDs		2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
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