KMT2E and ALKBH4

Data Source:
BioGRID (affinity chromatography technology)

		KMT2E	ALKBH4
Description		lysine methyltransferase 2E (inactive)	alkB homolog 4, lysine demethylase
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin	Nucleolus Cytoplasm Midbody Contractile Ring
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding	Actin Binding Protein Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Demethylase Activity Oxidative DNA Demethylase Activity Metal Ion Binding
	Biological Process	Neutrophil Mediated Immunity DNA Methylation Cell Cycle Arrest Erythrocyte Differentiation Histone Lysine Methylation Neutrophil Activation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation	Chromatin Organization Protein Demethylation Actomyosin Structure Organization Oxidative DNA Demethylation Cleavage Furrow Ingression Oxidative Demethylation DNA Demethylation Regulation Of Chromatin Organization
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)	Morning person ( 30696823)
Interacting Genes		4 interacting genes: ASH2L ATP13A1 CDK1 LAMTOR5	18 interacting genes: BPIFA1 DTX2 EIF3C EP300 FAM168A GORASP2 HSF4 LCN2 MLLT1 MLLT3 MTMR6 NIF3L1 PSMA6 TCF4 TES TRAF4 TXNL4B ZFHX3
Entrez ID		55904	54784
HPRD ID		10528	07875
Ensembl ID		ENSG00000005483	ENSG00000160993
Uniprot IDs		Q8IZD2	Q9NXW9
PDB IDs		2LV9 4L58 5HT6
Enriched GO Terms of Interacting Partners?
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