KMT2E and ZCWPW1

Data Source:
BioGRID (affinity chromatography technology)

		KMT2E	ZCWPW1
Description		lysine methyltransferase 2E (inactive)	zinc finger CW-type and PWWP domain containing 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Plasma Membrane Nuclear Body Nuclear Speck Protein-containing Complex Transcriptionally Active Chromatin	Nucleus Chromosome
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity Enzyme Binding Methylated Histone Binding Metal Ion Binding	Zinc Ion Binding Methyl-CpG Binding Methylated Histone Binding
	Biological Process	Neutrophil Mediated Immunity DNA Methylation Cell Cycle Arrest Erythrocyte Differentiation Histone Lysine Methylation Neutrophil Activation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Histone H3-K4 Trimethylation	Meiosis I Homologous Chromosome Pairing At Meiosis Spermatogenesis Cell Differentiation Positive Regulation Of DNA Recombination Positive Regulation Of Double-strand Break Repair
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Autism spectrum disorder ( 30804558) Autism spectrum disorder or schizophrenia ( 28540026) General risk tolerance (MTAG) ( 30643258) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494) Schizophrenia ( 29483656)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Brain morphology (MOSTest) ( 32665545) Family history of Alzheimer's disease ( 30617256) Hemoglobin levels ( 32327693) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 32888494) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: ASH2L ATP13A1 CDK1 LAMTOR5	3 interacting genes: L3MBTL3 MEOX2 VAC14
Entrez ID		55904	55063
HPRD ID		10528	15706
Ensembl ID		ENSG00000005483	ENSG00000078487
Uniprot IDs		Q8IZD2	Q9H0M4
PDB IDs		2LV9 4L58 5HT6	2E61 2RR4
Enriched GO Terms of Interacting Partners?
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