SOCS6 and IRS4

Number of citations of the paper that reports this interaction (PubMedID 12052866)
41

Data Source:
HPRD (in vitro)

		SOCS6	IRS4
Description		suppressor of cytokine signaling 6	insulin receptor substrate 4
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex	Cytosol Plasma Membrane
	Molecular Function	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Defense Response Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphate Biosynthetic Process Negative Regulation Of T Cell Activation	Signal Transduction Insulin Receptor Signaling Pathway
Pathways		Regulation of KIT signaling Neddylation Negative regulation of FLT3	IRS-related events triggered by IGF1R
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)
Interacting Genes		40 interacting genes: ACVR1 AMOT APPL1 AR BMPR1B C1orf109 CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 PIK3R3 PITRM1 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2	23 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MTNR1A MTNR1B NDN NISCH OGT PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG
Entrez ID		9306	8471
HPRD ID		05491	04620
Ensembl ID		ENSG00000170677	ENSG00000133124
Uniprot IDs		A0A024R379 O14544	O14654
PDB IDs		2VIF
Enriched GO Terms of Interacting Partners?
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