IRS4 and NISCH

Number of citations of the paper that reports this interaction (PubMedID 11912194)
11

Data Source:
HPRD (in vivo)

		IRS4	NISCH
Description		insulin receptor substrate 4	nischarin
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Early Endosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Intracellular Membrane-bounded Organelle Intercellular Bridge Recycling Endosome
	Molecular Function	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding	Integrin Binding Protein Binding Protein Kinase Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway	Glucose Metabolic Process Apoptotic Process Regulation Of Blood Pressure Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Norepinephrine Secretion
Pathways		IRS-related events triggered by IGF1R	RAC1 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle
Drugs			Tizanidine Agmatine Moxonidine
Diseases
GWAS			Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Body shape index ( 34021172) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Parkinson's disease ( 28892059) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 25056061 29483656 23974872) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		23 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MTNR1A MTNR1B NDN NISCH OGT PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG	6 interacting genes: AR IRS4 ITGA5 OGT PTGER4 TWF2
Entrez ID		8471	11188
HPRD ID		04620	11391
Ensembl ID		ENSG00000133124	ENSG00000010322
Uniprot IDs		O14654	Q9Y2I1
PDB IDs			3P0C
Enriched GO Terms of Interacting Partners?
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