ACY3 and MAP3K8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		ACY3	MAP3K8
Description		aminoacylase 3	mitogen-activated protein kinase kinase kinase 8
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Apical Plasma Membrane Extracellular Exosome	Cytosol
	Molecular Function	Molecular_function Aminoacylase Activity Protein Binding Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Biological_process	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation
Pathways		Aflatoxin activation and detoxification	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 33031748 24625756) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Waist circumference adjusted for body mass index ( 34021172)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		21 interacting genes: AAMDC ARF5 ASPA CYSRT1 DDIT4L GORASP2 INCA1 KRTAP10-3 KRTAP10-8 KRTAP15-1 KRTAP26-1 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 PTGER4 RARG RRAS	26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		91703	1326
HPRD ID		12422	01863
Ensembl ID		ENSG00000132744	ENSG00000107968
Uniprot IDs		A0A024R5L2 Q96HD9	P41279 Q6FG25
PDB IDs			4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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