MAP3K8 and STIP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		MAP3K8	STIP1
Description		mitogen-activated protein kinase kinase kinase 8	stress induced phosphoprotein 1
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GO Annotations	Cellular Component	Cytosol	Nucleus Golgi Apparatus Cytosol Protein-containing Complex Chaperone Complex Dynein Axonemal Particle
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	RNA Binding Protein Binding Protein C-terminus Binding Hsp70 Protein Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation	Cellular Response To Interleukin-7
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand RND1 GTPase cycle
Drugs			Copper
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Attention deficit hyperactivity disorder ( 21784300) Body shape index ( 34021172) Crohn's disease ( 28067908) Fruit consumption ( 32066663) Monocyte count ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	25 interacting genes: ACD ACVR1 AIP APP CDC37 CLCN1 CLK1 EGFR ERBB2 FKBP4 FKBP5 HSP90AA1 HSPA14 HSPA1A HSPA1B HSPA8 LMO2 MAP3K8 OGT POT1 PRNP PTGES3 SUMO2 SUMO4 YIF1A
Entrez ID		1326	10963
HPRD ID		01863	05454
Ensembl ID		ENSG00000107968	ENSG00000168439
Uniprot IDs		P41279 Q6FG25	P31948 V9HW72
PDB IDs		4Y83 4Y85 5IU2	1ELR 1ELW 2LNI 2NC9 3ESK 3FWV
Enriched GO Terms of Interacting Partners?
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