MAP3K8 and RANGAP1

		MAP3K8	RANGAP1
Description		mitogen-activated protein kinase kinase kinase 8	Ran GTPase activating protein 1
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GO Annotations	Cellular Component	Cytosol	Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Aggresome Dendrite Nuclear Membrane Intracellular Membrane-bounded Organelle Nuclear Pore Cytoplasmic Filaments Perinuclear Region Of Cytoplasm Mitotic Spindle Axon Cytoplasm Cytoplasmic Periphery Of The Nuclear Pore Complex
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	RNA Binding GTPase Activator Activity Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Cadherin Binding
	Biological Process	MAPK Cascade Protein Phosphorylation Cell Cycle T Cell Costimulation	Signal Transduction Negative Regulation Of Protein Export From Nucleus Response To Axon Injury Activation Of GTPase Activity Cellular Response To Vasopressin
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMO E3 ligases SUMOylate target proteins SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Bitter beverage consumption ( 31046077) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Lamb consumption ( 32066663) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		26 interacting genes: ACP6 ACY3 ADAM10 AKT1 BMPR2 CD40 CHUK GAD2 JCAD LYZL2 MAP2K1 MAP2K4 MAP3K14 MTPAP NFKB1 NFKB2 PARD3 PDK2 RANGAP1 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	23 interacting genes: AXIN2 CCL5 CSNK2A1 DLC1 GNAI1 GNAI3 IPO8 MAP3K8 MUL1 OGT PDGFRL PRKACA PTEN RAN RANBP2 SENP1 SENP2 SUMO1 SUMO2 SUMO3 UBE2E3 UBE2I USPL1
Entrez ID		1326	5905
HPRD ID		01863	03839
Ensembl ID		ENSG00000107968	ENSG00000100401
Uniprot IDs		P41279 Q6FG25	A0A024R1U0 P46060 Q9BSK3
PDB IDs		4Y83 4Y85 5IU2	1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2IO2 2IO3 2IY0 3UIN 3UIO 3UIP 5D2M
Enriched GO Terms of Interacting Partners?
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