ARHGEF1 and ATR

Number of citations of the paper that reports this interaction (PubMedID 10608806)
272

Data Source:
BioGRID (unspecified method)

		ARHGEF1	ATR
Description		Rho guanine nucleotide exchange factor 1	ATR serine/threonine kinase
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Golgi Apparatus PML Body
	Molecular Function	G Protein-coupled Receptor Binding RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Serine Kinase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	DNA Damage Checkpoint Signaling Telomere Maintenance DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Multicellular Organism Development Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Peptidyl-serine Phosphorylation Replication Fork Processing Positive Regulation Of Telomere Maintenance Via Telomerase Cellular Response To UV Interstrand Cross-link Repair Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Protein Localization To Chromosome, Telomeric Region Cellular Response To Gamma Radiation Replicative Senescence Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Regulation Of Cellular Response To Heat Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Hallux valgus ( 32131869)	Eosinophil counts ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 29403010 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Red cell distribution width ( 32888494 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		11 interacting genes: ATR CD44 CNKSR1 CSNK1E GNA13 HRAS PRKCA RAP1A RHOA SREBF2 TCF4	50 interacting genes: AATF ABL1 AP1B1 AP3B1 ARHGEF1 ATM BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CHUK CLSPN CREB1 DCAF1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 ETV1 FANCA FANCD2 FANCI FLT1 H2AX KDR LIG4 MCM2 MCPH1 MRE11 MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R3A RAD17 RASSF1 RHEB TP53 TREX1 UPF1 XPA XRCC5
Entrez ID		9138	545
HPRD ID		03511	08369
Ensembl ID		ENSG00000076928	ENSG00000175054
Uniprot IDs		A0A024R0R1 Q92888	Q13535
PDB IDs		1IAP 1SHZ 3AB3 3ODO 3ODW 3ODX 3P6A	5YZ0
Enriched GO Terms of Interacting Partners?
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