IFT20 and NDC80

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		IFT20	NDC80
Description		intraflagellar transport 20	NDC80 kinetochore complex component
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Golgi Apparatus Cis-Golgi Network Centrosome Centriole Microvillus Cilium Intraciliary Transport Particle B Motile Cilium Photoreceptor Connecting Cilium Stereocilium Dendrite Terminus Ciliary Tip Ciliary Base Kinociliary Basal Body	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex
	Molecular Function	Opsin Binding Protein Binding Small GTPase Binding	Protein Binding Identical Protein Binding
	Biological Process	Establishment Of Planar Polarity Kidney Development Smoothened Signaling Pathway Spermatogenesis Visual Learning Protein Localization To Golgi Apparatus Photoreceptor Cell Outer Segment Organization Opsin Transport Intraciliary Transport Establishment Of Epithelial Cell Apical/basal Polarity Centrosome Localization Cardiac Muscle Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Canonical Wnt Signaling Pathway Neural Precursor Cell Proliferation Protein Localization To Cilium Protein Localization To Plasma Membrane Cochlea Development Regulation Of Cilium Assembly Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Autophagosome Assembly	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centrosome Duplication Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore
Pathways		Intraflagellar transport Intraflagellar transport	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Osteoprotegerin levels ( 25080503)	Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		53 interacting genes: ABHD15 ABI2 ABI3 AQP1 BLOC1S6 C1orf216 CCHCR1 CD209 CLEC4M COASY CORO1A CROCCP2 DISC1 DTNBP1 EMILIN1 EXOC7 FAM81B FBF1 FSD2 GOLGA2 HAUS1 HLCS HTT IFT57 KAT5 KDM8 KIF3B KNSTRN KPNA2 KRT13 KXD1 MED30 MIS18A NDC80 NUP54 NUP62 OXNAD1 PBX4 PPP1R11 PSMA1 PTPN12 RAB11FIP4 RALGPS2 RASSF4 RICTOR SH3BP5 SYCE2 TP53I13 TREX1 USHBP1 WASF1 WASHC3 ZDHHC17	62 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CENPH CEP63 CKAP5 EPS15L1 EXOC8 FAM9C GOLGA2 HAUS1 HGS HPCA IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 MX1 NDE1 NDEL1 NEK2 NUF2 PFDN1 PPP1R13B PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 THOC7 TOM1L1 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT
Entrez ID		90410	10403
HPRD ID		17137	06277
Ensembl ID		ENSG00000109083	ENSG00000080986
Uniprot IDs		A0A024QZ08 A0A087X2B4 Q8IY31	A8K031 O14777
PDB IDs			2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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