NDC80 and ATP6V1D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NDC80	ATP6V1D
Description		NDC80 kinetochore complex component	ATPase H+ transporting V1 subunit D
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex	Lysosomal Membrane Centrosome Cytosol Plasma Membrane Cilium Membrane Proton-transporting V-type ATPase Complex Specific Granule Membrane Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Centrosome Duplication Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore	Regulation Of Macroautophagy Cilium Assembly Protein Localization To Cilium Proton Transmembrane Transport
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)
Interacting Genes		62 interacting genes: AMOTL2 ATF4 ATP5PO ATP6V1D AURKA AURKB BLOC1S6 CAGE1 CALCOCO1 CCDC136 CCHCR1 CCNH CCNK CENPH CEP63 CKAP5 EPS15L1 EXOC8 FAM9C GOLGA2 HAUS1 HGS HPCA IFT20 INPP1 KIFC3 KLC3 KLHL12 KRT27 KRT6B KRT75 LNX1 MAD1L1 MAD2L1 MFAP1 MIS12 MX1 NDE1 NDEL1 NEK2 NUF2 PFDN1 PPP1R13B PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 THOC7 TOM1L1 TXLNA USHBP1 VPS52 WASHC1 WASHC3 ZNF655 ZWINT	8 interacting genes: ATP6V1F BBLN GOLGA2 HAUS1 KRT27 NDC80 TOMM34 VPS52
Entrez ID		10403	51382
HPRD ID		06277	16524
Ensembl ID		ENSG00000080986	ENSG00000100554
Uniprot IDs		A8K031 O14777	A0A024R683 Q9Y5K8
PDB IDs		2IGP 2VE7 3IZ0	6WLZ 6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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