IFT20 and DISC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IFT20	DISC1
Description		intraflagellar transport 20	DISC1 scaffold protein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Golgi Apparatus Cis-Golgi Network Centrosome Centriole Microvillus Cilium Intraciliary Transport Particle B Motile Cilium Photoreceptor Connecting Cilium Stereocilium Dendrite Terminus Ciliary Tip Ciliary Base Kinociliary Basal Body	Nucleus Mitochondrion Endoplasmic Reticulum Centrosome Cytosol Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Dynein Complex Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base
	Molecular Function	Opsin Binding Protein Binding Small GTPase Binding	Protein Binding Kinesin Binding Protein-containing Complex Binding Molecular Adaptor Activity
	Biological Process	Establishment Of Planar Polarity Kidney Development Smoothened Signaling Pathway Spermatogenesis Visual Learning Protein Localization To Golgi Apparatus Photoreceptor Cell Outer Segment Organization Opsin Transport Intraciliary Transport Establishment Of Epithelial Cell Apical/basal Polarity Centrosome Localization Cardiac Muscle Cell Differentiation Inner Ear Receptor Cell Stereocilium Organization Cilium Assembly Regulation Of Canonical Wnt Signaling Pathway Neural Precursor Cell Proliferation Protein Localization To Cilium Protein Localization To Plasma Membrane Cochlea Development Regulation Of Cilium Assembly Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Autophagosome Assembly	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Proliferation In Forebrain Pyramidal Neuron Migration To Cerebral Cortex Positive Regulation Of Wnt Signaling Pathway TOR Signaling Negative Regulation Of Protein Binding Positive Regulation Of Axon Extension Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Cilium Assembly Regulation Of Dendritic Spine Development Protein Localization To Centrosome Regulation Of Synapse Maturation Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Osteoprotegerin levels ( 25080503)	Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Bell's palsy ( 33602968) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Waist circumference ( 28552196)
Interacting Genes		53 interacting genes: ABHD15 ABI2 ABI3 AQP1 BLOC1S6 C1orf216 CCHCR1 CD209 CLEC4M COASY CORO1A CROCCP2 DISC1 DTNBP1 EMILIN1 EXOC7 FAM81B FBF1 FSD2 GOLGA2 HAUS1 HLCS HTT IFT57 KAT5 KDM8 KIF3B KNSTRN KPNA2 KRT13 KXD1 MED30 MIS18A NDC80 NUP54 NUP62 OXNAD1 PBX4 PPP1R11 PSMA1 PTPN12 RAB11FIP4 RALGPS2 RASSF4 RICTOR SH3BP5 SYCE2 TP53I13 TREX1 USHBP1 WASF1 WASHC3 ZDHHC17	194 interacting genes: ABI2 ACTG1 ACTN2 ADO AGTPBP1 AIMP2 AKAP6 ALDH3A2 AMOT AP1M1 ARIH2 ARMC7 ATF4 ATF5 ATF7IP BAG2 BFSP2 BICD1 BORCS6 BRD1 C1orf109 C2CD6 C8orf33 CARD9 CCDC102B CCDC13 CCDC136 CCDC141 CCDC197 CCDC24 CCDC57 CCDC88A CCDC92 CCHCR1 CDC23 CDC37 CDC5L CDK5RAP3 CDKL3 CEP126 CEP57 CEP57L1 CEP63 CFAP206 CIT CLU CNST COL4A1 CTNNA3 CWF19L2 DCTN1 DCTN2 DDX6 DEGS1 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EGLN1 EIF3H EIF4A3 EMSY EXOC1 EXOC4 EXOC7 EXTL1 FBXO34 FBXO41 FBXW7 FEZ1 FLACC1 FRYL GABARAPL1 GAS2L2 GAS8 GCC1 GEM GNB1 GNG13 GNPTAB GPANK1 GPRASP2 GRIPAP1 GSK3B HERC2P2 HNRNPC IFT20 IFT74 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIF9 KIFAP3 KIFC3 LENG1 MACF1 MAP1A MEMO1 MLLT10 MNS1 MORF4L2 MPPED1 MVP MYH7 MYT1L NCK2 NDE1 NDEL1 NECAB1 NEFM NME7 NSRP1 NUP160 OLFM1 PCNT PCNX4 PDE4B PGK1 PHF1 PIBF1 PIK3R3 PKN1 POLR3C PPFIA3 PPM1E PPP4R1 PPP5C PSPC1 QARS1 RABGAP1 RAD21 RANBP9 RASSF7 RBM41 RBSN RECK RNF40 ROGDI RTRAF SH3BP5 SMARCD1 SMARCE1 SMC2 SMC3 SMC5 SMYD1 SNX6 SPARCL1 SPATC1L SPTBN4 SRGAP2 SRGAP3 STX11 STX18 SUFU SYBU SYNE1 TCAF1 TCEANC TFIP11 TIAM2 TNKS TP53BP2 TRAF3IP1 TRAF4 TRIM29 TRIM68 TRIO TSGA10 TSPOAP1 TSR2 TTC23 TUBB TUBB2A UBASH3A UBASH3B USP2 UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF124 ZNF197 ZNF365 ZNF76
Entrez ID		90410	27185
HPRD ID		17137	05553
Ensembl ID		ENSG00000109083	ENSG00000162946
Uniprot IDs		A0A024QZ08 A0A087X2B4 Q8IY31	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs			5V4B
Enriched GO Terms of Interacting Partners?
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