TNFRSF18 and DZIP3

		TNFRSF18	DZIP3
Description		TNF receptor superfamily member 18	DAZ interacting zinc finger protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Cytoplasm
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Phosphatase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion	Protein Polyubiquitination
Pathways		TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		13 interacting genes: AKR1C1 ARHGEF16 BTK DZIP3 KCNAB2 LGALS8 LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2 WRAP73	53 interacting genes: AKTIP AP1M1 ARHGAP32 ATXN1 BAG4 BIRC2 BIRC3 CARM1 CEP63 DAZ1 FBXO17 GRIP1 GTF2H2C_2 HNRNPF HNRNPH1 HNRNPUL1 HOTAIR HOXC8 MIR20A MIR29C NCOR1 PCGF3 PITX1 RAD18 RBM4B RNF38 RUNX1 TNFRSF18 TNS2 TOLLIP TRIM21 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2N UBE2R2 UBE2U UBE2V1 UBE2V2 UBE2W UBE2Z UBR3 ZCCHC10 ZNF24 ZNF765
Entrez ID		8784	9666
HPRD ID		04879	10562
Ensembl ID		ENSG00000186891	ENSG00000198919
Uniprot IDs		A0A0R7FDM1 Q9Y5U5	Q86Y13
PDB IDs		7KHD
Enriched GO Terms of Interacting Partners?
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