TNFRSF18 and ARHGEF16

		TNFRSF18	ARHGEF16
Description		TNF receptor superfamily member 18	Rho guanine nucleotide exchange factor 16
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Cytosol
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Cadherin Binding
	Biological Process	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion	Cell Chemotaxis Activation Of GTPase Activity Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Response to statin therapy ( 20339536)
Interacting Genes		13 interacting genes: AKR1C1 ARHGEF16 BTK DZIP3 KCNAB2 LGALS8 LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2 WRAP73	10 interacting genes: CKAP5 HNRNPH1 LASP1 LMNA LNX1 MAGED1 MAPK1IP1L TFG TNFRSF18 YWHAQ
Entrez ID		8784	27237
HPRD ID		04879	12478
Ensembl ID		ENSG00000186891	ENSG00000130762
Uniprot IDs		A0A0R7FDM1 Q9Y5U5	B3KTS4 Q5VV41
PDB IDs		7KHD	1X6B
Enriched GO Terms of Interacting Partners?
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