TNFRSF18 and KCNAB2

		TNFRSF18	KCNAB2
Description		TNF receptor superfamily member 18	potassium voltage-gated channel subfamily A regulatory beta subunit 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Cytosol Microtubule Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Specific Granule Membrane Juxtaparanode Region Of Axon Synapse Tertiary Granule Membrane Pinceau Fiber
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding	Aldo-keto Reductase (NADP) Activity Voltage-gated Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Transmembrane Transporter Binding D-threo-aldose 1-dehydrogenase Activity
	Biological Process	Positive Regulation Of Leukocyte Migration Apoptotic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion	NADPH Oxidation Potassium Ion Transmembrane Transport Regulation Of Action Potential Regulation Of Potassium Ion Transmembrane Transport Regulation Of Protein Localization To Cell Surface
Pathways		TNFs bind their physiological receptors RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Voltage gated Potassium channels Neutrophil degranulation
Drugs			Enflurane Promethazine Miconazole
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: AKR1C1 ARHGEF16 BTK DZIP3 KCNAB2 LGALS8 LNX1 TNFSF18 TRAF1 TRAF2 TRAF3 UBQLN2 WRAP73	10 interacting genes: ATXN1 CD4 FAM3B KCNA2 NEDD4 NEDD4L SLC39A1 SLC39A2 SQSTM1 TNFRSF18
Entrez ID		8784	8514
HPRD ID		04879	03090
Ensembl ID		ENSG00000186891	ENSG00000069424
Uniprot IDs		A0A0R7FDM1 Q9Y5U5	A1PR14 B2R776 Q13303
PDB IDs		7KHD	1ZSX
Enriched GO Terms of Interacting Partners?
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