NOP14 and NSD2

		NOP14	NSD2
Description		NOP14 nucleolar protein	nuclear receptor binding SET domain protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Membrane 90S Preribosome Noc4p-Nop14p Complex Small-subunit Processome	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	RNA Binding Enzyme Binding SnoRNA Binding	Chromatin Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific) Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage To Generate Mature 5'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Household income (MTAG) ( 31844048) Huntington's disease progression ( 28642124) Smoking behaviour (cigarettes smoked per day) ( 30679032)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		1 interacting genes: NSD2	17 interacting genes: AGO2 APP AR AURKA BRCA1 ESR1 H3-4 H3C14 HORMAD2 MDC1 NELFA NOP14 PCNA PLEKHF2 SH3BP2 SLBP SMURF1
Entrez ID		8602	7468
HPRD ID		12827	04259
Ensembl ID		ENSG00000087269	ENSG00000109685
Uniprot IDs		A8KA74 P78316	O96028
PDB IDs			5LSU 5VC8 6UE6 6XCG 7CRO
Enriched GO Terms of Interacting Partners?
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