NSD2 and SH3BP2

		NSD2	SH3BP2
Description		nuclear receptor binding SET domain protein 2	SH3 domain binding protein 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific) Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	Phosphotyrosine Residue Binding Protein Binding SH3 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Signal Transduction
Pathways		PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Hodgkin's lymphoma ( 34216518) Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)
Interacting Genes		17 interacting genes: AGO2 APP AR AURKA BRCA1 ESR1 H3-4 H3C14 HORMAD2 MDC1 NELFA NOP14 PCNA PLEKHF2 SH3BP2 SLBP SMURF1	32 interacting genes: ABL1 ARHGAP10 CTTN DBNL ERBB2 ERBB3 ERBB4 FGFR1 FLT3 FYN GRB2 HCLS1 KIT LAT LCK MET MYO1F NSD2 PDLIM7 PLCG1 PLCG2 SH3KBP1 SH3RF1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70
Entrez ID		7468	6452
HPRD ID		04259	03657
Ensembl ID		ENSG00000109685	ENSG00000087266
Uniprot IDs		O96028	A0A384N6E5 P78314
PDB IDs		5LSU 5VC8 6UE6 6XCG 7CRO	2CR4 3TWR
Enriched GO Terms of Interacting Partners?
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