NSD2 and NELFA

		NSD2	NELFA
Description		nuclear receptor binding SET domain protein 2	negative elongation factor complex member A
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleoplasm Cytosol Nuclear Body NELF Complex
	Molecular Function	Chromatin Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific) Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	Chromatin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Multicellular Organism Development Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Histone H3-K4 Methylation
Pathways		PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		17 interacting genes: AGO2 APP AR AURKA BRCA1 ESR1 H3-4 H3C14 HORMAD2 MDC1 NELFA NOP14 PCNA PLEKHF2 SH3BP2 SLBP SMURF1	12 interacting genes: APP CDK3 MLH1 NCK2 NELFCD NSD2 OPRM1 PIN1 PRR22 SH3KBP1 SIAH1 SMARCD1
Entrez ID		7468	7469
HPRD ID		04259	12080
Ensembl ID		ENSG00000109685	ENSG00000185049
Uniprot IDs		O96028	A0A0C4DFX9 Q9H3P2
PDB IDs		5LSU 5VC8 6UE6 6XCG 7CRO	5L3X 6GML
Enriched GO Terms of Interacting Partners?
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