NSD2

Description		nuclear receptor binding SET domain protein 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Chromatin Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific) Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		17 interacting genes: AGO2 APP AR AURKA BRCA1 ESR1 H3-4 H3C14 HORMAD2 MDC1 NELFA NOP14 PCNA PLEKHF2 SH3BP2 SLBP SMURF1
Entrez ID		7468
HPRD ID		04259
Ensembl ID		ENSG00000109685
Uniprot IDs		O96028
PDB IDs		5LSU 5VC8 6UE6 6XCG 7CRO
Enriched GO Terms of Interacting Partners?
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