CUL2 and GPS1

Number of citations of the paper that reports this interaction (PubMedID 11337588)
246

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		CUL2	GPS1
Description		cullin 2	G protein pathway suppressor 1
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex	Nucleoplasm Cytosol COP9 Signalosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	GTPase Inhibitor Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway	Protein Deneddylation JNK Cascade Negative Regulation Of Catalytic Activity
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		35 interacting genes: ABI1 ARID1B CAND1 CCND1 CDC34 CHD3 COMMD1 COPS5 CREM DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 FZD8 GJD4 GPS1 HSD17B7P2 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 UBE2D3 VHL ZER1 ZNF25 ZYG11B	30 interacting genes: CNOT2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL5 DDB1 ELOB IP6K1 ITPK1 OGT RBX1 SAP130 SENP8 SHANK3 SKP1 SKP2 TBC1D17 TP53 TRIM55 TRIM63 VHL
Entrez ID		8453	2873
HPRD ID		06786	15991
Ensembl ID		ENSG00000108094	ENSG00000169727
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617	A0A096LP07 A0A096LPJ3 C9JFE4 Q13098
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N	4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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