CUL2 and KHNYN

Number of citations of the paper that reports this interaction (PubMedID 30659753)
6

Data Source:
BioGRID (pull down)

		CUL2	KHNYN
Description		cullin 2	KH and NYN domain containing
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex	Cellular_component Nucleus Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	Molecular_function MRNA Binding Endoribonuclease Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway	Biological_process RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		35 interacting genes: ABI1 ARID1B CAND1 CCND1 CDC34 CHD3 COMMD1 COPS5 CREM DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 FZD8 GJD4 GPS1 HSD17B7P2 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 UBE2D3 VHL ZER1 ZNF25 ZYG11B	5 interacting genes: CUL1 CUL2 HECTD1 PLOD3 TEPSIN
Entrez ID		8453	23351
HPRD ID		06786	11076
Ensembl ID		ENSG00000108094	ENSG00000100441
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617	A8K6L5 O15037
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N	2N5M 2N7K
Enriched GO Terms of Interacting Partners?
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