GPS1 and COPS2

Number of citations of the paper that reports this interaction (PubMedID 11337588)
246

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		GPS1	COPS2
Description		G protein pathway suppressor 1	COP9 signalosome subunit 2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol COP9 Signalosome	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome
	Molecular Function	GTPase Inhibitor Activity Protein Binding	Transcription Corepressor Activity Protein Binding
	Biological Process	Protein Deneddylation JNK Cascade Negative Regulation Of Catalytic Activity	Negative Regulation Of Transcription By RNA Polymerase II Protein Deneddylation Inner Cell Mass Cell Proliferation Transcription By RNA Polymerase II Protein Phosphorylation Signal Transduction Neuron Differentiation Skeletal Muscle Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation RHOBTB1 GTPase cycle
Drugs
Diseases
GWAS			Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		30 interacting genes: CNOT2 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPS9 CUL1 CUL2 CUL3 CUL5 DDB1 ELOB IP6K1 ITPK1 OGT RBX1 SAP130 SENP8 SHANK3 SKP1 SKP2 TBC1D17 TP53 TRIM55 TRIM63 VHL	40 interacting genes: COPS3 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 CSNK2A1 CUL4B CUL5 DDB1 EP300 GFER GPS1 H3C1 H4C1 ING1 ING2 IP6K1 IRF8 MAP3K10 MAPK8 NCOR1 NIF3L1 NR0B1 NR2F1 OGT PRKD1 PSMD11 RARA RND1 RXRA SENP8 SIN3A SIN3B THRA THRB TP53 VDR ZNF446
Entrez ID		2873	9318
HPRD ID		15991	05146
Ensembl ID		ENSG00000169727	ENSG00000166200
Uniprot IDs		A0A096LP07 A0A096LPJ3 C9JFE4 Q13098	P61201 Q59EL2
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	4D10 4D18 4WSN 6A73 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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