CUL2 and CHD3

		CUL2	CHD3
Description		cullin 2	chromodomain helicase DNA binding protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome NuRD Complex PML Body Centriolar Satellite
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding	Transcription Cis-regulatory Region Binding DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding ATP Hydrolysis Activity Double-stranded DNA Helicase Activity ATP-dependent Chromatin Remodeler Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spindle Organization Centrosome Cycle DNA Duplex Unwinding
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Ischemic stroke ( 26089329) Macular thickness ( 30535121) Prostate cancer ( 29892016) Refractive error ( 32231278) Stroke ( 26089329)
Interacting Genes		35 interacting genes: ABI1 ARID1B CAND1 CCND1 CDC34 CHD3 COMMD1 COPS5 CREM DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC FNIP1 FZD8 GJD4 GPS1 HSD17B7P2 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 UBE2D3 VHL ZER1 ZNF25 ZYG11B	100 interacting genes: ACTR1B ADH5 AIMP2 ATP5IF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CBX4 CHMP2A CPE CRCT1 CREB1 CREBBP CSTF2 CTBP1 CTTN CUL2 ENTR1 FABP4 FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HDAC2 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MX1 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RETREG2 RGS2 RIF1 RPL29 SAFB SAT1 SATB1 SERBP1 SERF2 SGSM2 SIRT6 SKIL SLC27A6 SPOP SRRT SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TRIM54 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBC UBE2I UROD VIM XRCC4 YAE1 ZHX1
Entrez ID		8453	1107
HPRD ID		06786	09071
Ensembl ID		ENSG00000108094	ENSG00000170004
Uniprot IDs		A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617	B3KWV4 Q12873 Q2TAZ1
PDB IDs		4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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