PIP4K2B and KYNU

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PIP4K2B	KYNU
Description		phosphatidylinositol-5-phosphate 4-kinase type 2 beta	kynureninase
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Autophagosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding ATP Binding GTP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Protein Homodimerization Activity	Pyridoxal Phosphate Binding Kynureninase Activity Protein Homodimerization Activity 3-hydroxykynureninase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Autophagosome-lysosome Fusion Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly	Tryptophan Catabolic Process Aging NAD Biosynthetic Process Tryptophan Catabolic Process To Kynurenine Tryptophan Catabolic Process To Acetyl-CoA Quinolinate Biosynthetic Process Response To Interferon-gamma 'de Novo' NAD Biosynthetic Process From Tryptophan Response To Vitamin B6 Anthranilate Metabolic Process L-kynurenine Catabolic Process
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus	Tryptophan catabolism
Drugs		Fostamatinib	Pyridoxal phosphate Alanine m-Hydroxyhippuric acid
Diseases
GWAS		Height ( 28552196 20881960 31562340)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Blood protein levels ( 30072576 29875488 28240269) Cataracts ( 34127677) Empathy quotient ( 29527006) Glomerular filtration rate in chronic kidney disease ( 26420894) Neurological blood protein biomarker levels ( 31320639) Platelet count ( 32888494) Response to SSRI (symptom remission) ( 29160301) Toenail selenium levels ( 25343990)
Interacting Genes		17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131	9 interacting genes: CDC42 CT55 CTBP2 FAM86C1P LMO4 MCCD1 MYOZ3 PIP4K2B RASSF3
Entrez ID		8396	8942
HPRD ID		04463	08940
Ensembl ID		ENSG00000276293	ENSG00000115919
Uniprot IDs		P78356	Q16719
PDB IDs		1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H	2HZP 3E9K
Enriched GO Terms of Interacting Partners?
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