PIP4K2B and HSPB7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PIP4K2B	HSPB7
Description		phosphatidylinositol-5-phosphate 4-kinase type 2 beta	heat shock protein family B (small) member 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Autophagosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cajal Body Actin Cytoskeleton Aggresome
	Molecular Function	Protein Binding ATP Binding GTP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Protein Homodimerization Activity	Protein Binding Protein C-terminus Binding Filamin Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Autophagosome-lysosome Fusion Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly	Response To Unfolded Protein Heart Development Regulation Of Heart Contraction
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs		Fostamatinib
Diseases
GWAS		Height ( 28552196 20881960 31562340)	Arterial stiffness index ( 31235810) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erectile dysfunction ( 30583798) Hypertrophic cardiomyopathy ( 33495596 33495597) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Systolic blood pressure ( 28739976)
Interacting Genes		17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131	20 interacting genes: APP BAG3 C22orf15 CEP76 DDIT4L DYNLT1 FLNA GUCD1 HSPB8 PDLIM7 PIP4K2B PLEKHF2 PRDM14 REL RERE SF3B4 SYCE1 TCF4 TEPSIN TRIM23
Entrez ID		8396	27129
HPRD ID		04463	13684
Ensembl ID		ENSG00000276293	ENSG00000173641
Uniprot IDs		P78356	Q9UBY9
PDB IDs		1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H
Enriched GO Terms of Interacting Partners?
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