ADAMTS12 and MYL6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		ADAMTS12	MYL6
Description		ADAM metallopeptidase with thrombospondin type 1 motif 12	myosin light chain 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Cytosol Brush Border Membrane Myosin Complex Unconventional Myosin Complex Vesicle Extracellular Exosome
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metal Ion Binding	Microfilament Motor Activity Cytoskeletal Motor Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle
	Biological Process	Cell-matrix Adhesion Cell Migration Proteoglycan Catabolic Process Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation Regulation Of Inflammatory Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To BMP Stimulus Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus	Muscle Contraction Skeletal Muscle Tissue Development Muscle Filament Sliding
Pathways		Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Height ( 31217584) Metabolite levels ( 23823483) Mortality in heart failure ( 20400778) Neurofibrillary tangles ( 31497858) Seasonality and depression ( 30217971) Stroke (pediatric) ( 22990015)	Asthma ( 31619474)
Interacting Genes		7 interacting genes: CALM2 COIL IHO1 MEOX2 MYL6 TP53BP2 TRIM14	10 interacting genes: ADAMTS12 CYP27B1 DNAJB9 EWSR1 GLP1R GSK3B HMGB2 MLH1 MOB4 NUDT21
Entrez ID		81792	4637
HPRD ID		05862	17618
Ensembl ID		ENSG00000151388	ENSG00000092841
Uniprot IDs		D6REX0 P58397	P60660
PDB IDs
Enriched GO Terms of Interacting Partners?
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