MYL6 and CYP27B1

		MYL6	CYP27B1
Description		myosin light chain 6	cytochrome P450 family 27 subfamily B member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Brush Border Membrane Myosin Complex Unconventional Myosin Complex Vesicle Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Outer Membrane
	Molecular Function	Microfilament Motor Activity Cytoskeletal Motor Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle	Calcidiol 1-monooxygenase Activity Iron Ion Binding Heme Binding Secalciferol 1-monooxygenase Activity
	Biological Process	Muscle Contraction Skeletal Muscle Tissue Development Muscle Filament Sliding	Vitamin Metabolic Process Calcium Ion Transport Negative Regulation Of Cell Population Proliferation Negative Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D 24-hydroxylase Activity Bone Mineralization Negative Regulation Of Cell Growth Regulation Of Bone Mineralization Response To Lipopolysaccharide Response To Vitamin D Response To Interferon-gamma Calcitriol Biosynthetic Process From Calciol Vitamin D Metabolic Process Vitamin D Catabolic Process Response To Estrogen Positive Regulation Of Keratinocyte Differentiation Decidualization Calcium Ion Homeostasis G1 To G0 Transition Positive Regulation Of Vitamin D Receptor Signaling Pathway
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Vitamin D (calciferol) metabolism Vitamins Defective CYP27B1 causes VDDR1A
Drugs			Alfacalcidol
Diseases
GWAS		Asthma ( 31619474)	Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 19525955 21833088)
Interacting Genes		10 interacting genes: ADAMTS12 CYP27B1 DNAJB9 EWSR1 GLP1R GSK3B HMGB2 MLH1 MOB4 NUDT21	8 interacting genes: ATF2 HOXC10 ITGB7 MARS1 MYL6 SMC3 TMEM50B TUT4
Entrez ID		4637	1594
HPRD ID		17618	02031
Ensembl ID		ENSG00000092841	ENSG00000111012
Uniprot IDs		P60660	O15528
PDB IDs
Enriched GO Terms of Interacting Partners?
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