MYL6 and ADAMTS12

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		MYL6	ADAMTS12
Description		myosin light chain 6	ADAM metallopeptidase with thrombospondin type 1 motif 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Brush Border Membrane Myosin Complex Unconventional Myosin Complex Vesicle Extracellular Exosome	Extracellular Region Extracellular Matrix
	Molecular Function	Microfilament Motor Activity Cytoskeletal Motor Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle	Metalloendopeptidase Activity Protein Binding Metal Ion Binding
	Biological Process	Muscle Contraction Skeletal Muscle Tissue Development Muscle Filament Sliding	Cell-matrix Adhesion Cell Migration Proteoglycan Catabolic Process Extracellular Matrix Organization Negative Regulation Of Chondrocyte Differentiation Regulation Of Inflammatory Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To BMP Stimulus Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Cellular Response To Hepatocyte Growth Factor Stimulus
Pathways		EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Asthma ( 31619474)	Blond vs. brown/black hair color ( 30531825) Height ( 31217584) Metabolite levels ( 23823483) Mortality in heart failure ( 20400778) Neurofibrillary tangles ( 31497858) Seasonality and depression ( 30217971) Stroke (pediatric) ( 22990015)
Interacting Genes		10 interacting genes: ADAMTS12 CYP27B1 DNAJB9 EWSR1 GLP1R GSK3B HMGB2 MLH1 MOB4 NUDT21	7 interacting genes: CALM2 COIL IHO1 MEOX2 MYL6 TP53BP2 TRIM14
Entrez ID		4637	81792
HPRD ID		17618	05862
Ensembl ID		ENSG00000092841	ENSG00000151388
Uniprot IDs		P60660	D6REX0 P58397
PDB IDs
Enriched GO Terms of Interacting Partners?
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