NECTIN4 and AFDN

Number of citations of the paper that reports this interaction (PubMedID 11544254)
97

Data Source:
HPRD (in vitro)

		NECTIN4	AFDN
Description		nectin cell adhesion molecule 4	afadin, adherens junction formation factor
Image
GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Exosome	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction
	Molecular Function	Virus Receptor Activity Protein Binding Identical Protein Binding	Protein Binding Protein C-terminus Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Viral Entry Into Host Cell	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs		Enfortumab vedotin	(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS			Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT	39 interacting genes: BCR CCR6 CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RPS6KA2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		81607	4301
HPRD ID		17934	01164
Ensembl ID		ENSG00000143217	ENSG00000130396
Uniprot IDs		K4PZ75 Q96NY8	A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		4FRW 4GJT 4JJH	1T2M 1XZ9 2AIN 2EXG 5A6C
Enriched GO Terms of Interacting Partners?
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