AFDN and RRAS

Number of citations of the paper that reports this interaction (PubMedID 10224125)
29

Data Source:
HPRD (two hybrid, in vitro)

		AFDN	RRAS
Description		afadin, adherens junction formation factor	RAS related
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction	Plasma Membrane Focal Adhesion Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Leukocyte Differentiation Ras Protein Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Angiogenesis Regulation Of Protein Kinase B Signaling Face Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Positive Regulation Of Vasculogenesis
Pathways			SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Sema4D mediated inhibition of cell attachment and migration
Drugs		(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)	Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 27618447) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27618447)
Interacting Genes		39 interacting genes: BCR CCR6 CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RPS6KA2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	18 interacting genes: ACY3 AFDN ARAF BCL2 EEF1A1 EPHB2 MRPL36 NAV2 NCK1 PPP2CA RAF1 RALGDS RAP1GDS1 RASIP1 RASSF5 SOS1 TRIM55 TRIM63
Entrez ID		4301	6237
HPRD ID		01164	01299
Ensembl ID		ENSG00000130396	ENSG00000126458
Uniprot IDs		A8MQ02 G1UI22 J3KN01 P55196	A0A024QZF2 P10301
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C	2FN4
Enriched GO Terms of Interacting Partners?
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