AFDN and NECTIN4

Number of citations of the paper that reports this interaction (PubMedID 11544254)
97

Data Source:
HPRD (in vitro)

		AFDN	NECTIN4
Description		afadin, adherens junction formation factor	nectin cell adhesion molecule 4
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding	Virus Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Regulation Of Protein Localization Positive Regulation Of GTPase Activity Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Viral Entry Into Host Cell
Pathways			Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs		(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one	Enfortumab vedotin
Diseases
GWAS		Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		39 interacting genes: BCR CCR6 CTNNA1 EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RPS6KA2 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG	6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT
Entrez ID		4301	81607
HPRD ID		01164	17934
Ensembl ID		ENSG00000130396	ENSG00000143217
Uniprot IDs		A8MQ02 G1UI22 J3KN01 P55196	K4PZ75 Q96NY8
PDB IDs		1T2M 1XZ9 2AIN 2EXG 5A6C	4FRW 4GJT 4JJH
Enriched GO Terms of Interacting Partners?
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