EDEM3 and TXNDC5

Number of citations of the paper that reports this interaction (PubMedID 29784879)
10

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		EDEM3	TXNDC5
Description		ER degradation enhancing alpha-mannosidase like protein 3	thioredoxin domain containing 5
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Membrane Endoplasmic Reticulum Quality Control Compartment	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	Carbohydrate Metabolic Process Protein Glycosylation Response To Unfolded Protein Endoplasmic Reticulum Mannose Trimming Mannose Trimming Involved In Glycoprotein ERAD Pathway	Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance
Pathways		ER Quality Control Compartment (ERQC)	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body size at age 10 ( 32376654) Cerebrospinal fluid immune biomarker levels ( 32066700) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Waist circumference adjusted for body mass index ( 34021172)	Blood protein levels ( 30072576 29875488) High chromosomal aberration frequency (chromatid type) ( 31586183) Mean corpuscular hemoglobin ( 32888494) Pelvic organ prolapse ( 32184442)
Interacting Genes		4 interacting genes: CACYBP METTL13 TRA TXNDC5	28 interacting genes: APP AR BLZF1 EDEM3 EFEMP1 FLACC1 GMPPB KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 LHX4 MGAT5B NOTCH2NLA OGT PJA1 PRDX2 RAB3IP SPRY2 TRIM23 TRIM42 TRIP6 UBQLN2
Entrez ID		80267	81567
HPRD ID		10724	18249
Ensembl ID		ENSG00000116406	ENSG00000239264
Uniprot IDs		Q9BZQ6	A0A024QZV0 Q8NBS9
PDB IDs			2DIZ 3UJ1 3UVT 3WGD 3WGE 3WGX
Enriched GO Terms of Interacting Partners?
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