CXCR4 and ELANE

Number of citations of the paper that reports this interaction (PubMedID 12531874)
207

Data Source:
HPRD (in vitro)

		CXCR4	ELANE
Description		C-X-C motif chemokine receptor 4	elastase, neutrophil expressed
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cell Junction Cell Leading Edge Cytoplasmic Vesicle Protein-containing Complex Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Virus Receptor Activity Actin Binding G Protein-coupled Receptor Activity Protein Binding Coreceptor Activity C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding C-X-C Motif Chemokine 12 Receptor Activity Ubiquitin Binding	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding
	Biological Process	Response To Hypoxia Neuron Migration Epithelial Cell Development Dendritic Cell Chemotaxis Apoptotic Process Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Brain Development Neuron Recognition Response To Virus Response To Activity Calcium-mediated Signaling Neurogenesis Telencephalon Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Vascular Wound Healing CXCL12-activated CXCR4 Signaling Pathway Regulation Of Programmed Cell Death Myelin Maintenance Response To Morphine Endothelial Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Viral Process Regulation Of Chemotaxis Positive Regulation Of Chemotaxis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Regulation Of Calcium Ion Transport Cardiac Muscle Contraction Cell Chemotaxis Endothelial Tube Morphogenesis Cellular Response To Cytokine Stimulus Cellular Response To Xenobiotic Stimulus Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Dendrite Extension Positive Regulation Of Mesenchymal Stem Cell Migration Response To Ultrasound Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Negative Regulation Of Chemotaxis Pyroptosis Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events	Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade
Drugs		Framycetin AMD-070 Plerixafor Ibalizumab	Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 Freselestat Elafin
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arthritis (juvenile idiopathic) ( 27005825) Attention deficit hyperactivity disorder ( 32595297) Body mass index ( 26426971) Colorectal cancer ( 29228715) Estimated glomerular filtration rate ( 31152163) Lung function (low FEV1 vs high FEV1) ( 26423011) Monocyte count ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 19525953) Non-albumin protein levels ( 29403010) Smoking status (ever vs never smokers) ( 30643258) Telomere length ( 20421499) White blood cell count ( 32888494)	Blood protein levels ( 30072576)
Interacting Genes		43 interacting genes: ACAT1 AGO3 ARRB2 ATP13A2 B2M CCR5 CD4 CDRT15P3 CLCN5 COL4A1 CTSG CXCL12 DHX57 DPP4 DUXAP9 ELANE FTO GNA13 GNAI1 GRK3 HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC RALB RNF113A SCAMP2 SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1	30 interacting genes: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1
Entrez ID		7852	1991
HPRD ID		01217	00554
Ensembl ID		ENSG00000121966	ENSG00000197561
Uniprot IDs		A0A0U3FJG0 A0A0U3GXA9 P61073	P08246
PDB IDs		2K03 2K04 2K05 2N55 3ODU 3OE0 3OE6 3OE8 3OE9 4RWS	1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK
Enriched GO Terms of Interacting Partners?
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