ELANE and TFPI

Number of citations of the paper that reports this interaction (PubMedID 1558967)
31

Data Source:
HPRD (in vitro)

		ELANE	TFPI
Description		elastase, neutrophil expressed	tissue factor pathway inhibitor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Plasma Membrane Caveola Cell Surface Anchored Component Of Membrane
	Molecular Function	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Negative Regulation Of Chemotaxis Pyroptosis Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling	Blood Coagulation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Blood Coagulation Response To Estradiol Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Steroid Hormone Stimulus
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade	Extrinsic Pathway of Fibrin Clot Formation
Drugs		Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 Freselestat Elafin	Coagulation factor VIIa Recombinant Human Dalteparin Andexanet alfa
Diseases
GWAS		Blood protein levels ( 30072576)	Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diffusing capacity of carbon monoxide ( 30694715) Heart rate ( 23583979) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lung adenocarcinoma ( 28604730) Serum immune biomarker levels ( 32066700) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		30 interacting genes: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1	10 interacting genes: APP ELANE F10 MMP1 MMP12 MMP7 MMP8 MMP9 PRSS3 THBS1
Entrez ID		1991	7035
HPRD ID		00554	01064
Ensembl ID		ENSG00000197561	ENSG00000003436
Uniprot IDs		P08246	P10646
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK	1ADZ 1IRH 1TFX 4BQD 4DTG 5NMV 6BX8
Enriched GO Terms of Interacting Partners?
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