ELANE and CAMP

Number of citations of the paper that reports this interaction (PubMedID 11389039)
244

Data Source:
HPRD (in vitro)

		ELANE	CAMP
Description		elastase, neutrophil expressed	cathelicidin antimicrobial peptide
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Specific Granule Lumen Specific Granule Cell Projection Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	Lipopolysaccharide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Negative Regulation Of Chemotaxis Pyroptosis Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling	Positive Regulation Of Protein Phosphorylation Innate Immune Response In Mucosa Positive Regulation Of Cell Population Proliferation Antibacterial Humoral Response Defense Response To Bacterium Innate Immune Response Positive Regulation Of Angiogenesis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade	Neutrophil degranulation Antimicrobial peptides
Drugs		Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 Freselestat Elafin	Selenocysteine
Diseases
GWAS		Blood protein levels ( 30072576)	Blood protein levels ( 28240269)
Interacting Genes		30 interacting genes: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1	8 interacting genes: CTSG ELANE FPR2 GPX1 LBP MAPK8 PRTN3 RHOA
Entrez ID		1991	820
HPRD ID		00554	02722
Ensembl ID		ENSG00000197561	ENSG00000164047
Uniprot IDs		P08246	A0A384NPR0 J3KNB4 P49913
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK	2FBS 2FBU 2FCG 2K6O 2LMF 2NA3 4EYC 5NMN 5NNK 5NNM 5NNT 5XNG 5XRX 6BIV 6BIX 6S6M 6S6N
Enriched GO Terms of Interacting Partners?
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