ELANE and SERPINB1

Number of citations of the paper that reports this interaction (PubMedID 10924364)
1

Data Source:
HPRD (in vitro)

		ELANE	SERPINB1
Description		elastase, neutrophil expressed	serpin family B member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Cell Surface Transcription Repressor Complex Secretory Granule Azurophil Granule Lumen Specific Granule Lumen Phagocytic Vesicle Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Early Endosome Membrane Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Transcription Corepressor Activity Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Cytokine Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Yeast Acute Inflammatory Response To Antigenic Stimulus Leukocyte Migration Involved In Inflammatory Response Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Proteolysis Cellular Calcium Ion Homeostasis Phagocytosis Response To UV Extracellular Matrix Disassembly Protein Catabolic Process Response To Lipopolysaccharide Negative Regulation Of Chemokine Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-8 Production Defense Response To Bacterium Positive Regulation Of MAP Kinase Activity Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Immune Response Negative Regulation Of Chemotaxis Pyroptosis Neutrophil-mediated Killing Of Gram-negative Bacterium Neutrophil-mediated Killing Of Fungus Positive Regulation Of Leukocyte Tethering Or Rolling	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Interleukin-1 Beta Production Type B Pancreatic Cell Proliferation
Pathways		Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Pyroptosis Neutrophil degranulation Antimicrobial peptides Regulation of Complement cascade	Neutrophil degranulation
Drugs		Alpha-1-proteinase inhibitor Filgrastim Mdl 101,146 Freselestat Elafin
Diseases
GWAS		Blood protein levels ( 30072576)	BMI at 5 years old ( 31575865) Cerebrospinal fluid AB1-42 levels ( 28247064)
Interacting Genes		30 interacting genes: CAMP CSF3 CSF3R CXCL12 CXCR4 ELN F2R F2RL1 F5 GRN ITGAM KNG1 LPA LRP1 NOTCH2NLA SDC1 SERPINA1 SERPINA3 SERPINB1 SERPINB13 SERPIND1 SERPINE1 SERPINF2 SERPING1 SLPI TFPI TGFA THBS1 VCAM1 YARS1	4 interacting genes: CDC42 ELANE PRTN3 XPO1
Entrez ID		1991	1992
HPRD ID		00554	00555
Ensembl ID		ENSG00000197561	ENSG00000021355
Uniprot IDs		P08246	P30740 V9HWH1
PDB IDs		1B0F 1H1B 1HNE 1PPF 1PPG 2RG3 2Z7F 3Q76 3Q77 4NZL 4WVP 5A09 5A0A 5A0B 5A0C 5A8X 5A8Y 5A8Z 5ABW 6E69 6F5M 6SMA 7CBK	4GA7
Enriched GO Terms of Interacting Partners?
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