SLC30A2 and LTA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLC30A2	LTA
Description		solute carrier family 30 member 2	lymphotoxin alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Late Endosome Plasma Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Extracellular Space Plasma Membrane
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Identical Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Response To Zinc Ion Regulation Of Sequestering Of Zinc Ion Positive Regulation Of Sequestering Of Zinc Ion Zinc Ion Transmembrane Transport	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Xenobiotic Stimulus Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation
Pathways		Zinc efflux and compartmentalization by the SLC30 family	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs			Etanercept
Diseases
GWAS			Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body shape index ( 34021172) Crohn's disease ( 21102463) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Kawasaki disease ( 33106546) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Malaria ( 31844061) Monocyte count ( 32888494) Neonatal lupus ( 20662065) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Tumor necrosis factor levels ( 32805626) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252)
Interacting Genes		66 interacting genes: ABHD16A ADAM33 AQP2 AQP6 ATP13A1 C5orf46 CCL4 CCL4L2 CD40 CD52 CD79A CD99L2 CPLX4 CREB3 CTSA CYB561D2 EBAG9 EMP3 EVI2B F11R FAM174A FDPS FFAR2 FXYD3 FXYD6 GALNT15 GJA5 GJB2 GJB5 GLB1 GOLT1A GPR161 GPR42 GPRC5D HGFAC KASH5 KCNN4 LMNA LTA LYVE1 MS4A13 NDUFAF1 NRM OPRM1 PCNX2 PLPPR1 PVR SEC22A SELL SERPING1 SLC10A6 SLC16A2 SLC18A1 SLC38A7 SLC39A2 SLC7A1 SLC7A8 TAS2R5 TM4SF18 TMEM107 TMEM52B TMEM60 TMEM86A TNFRSF12A TRARG1 YIPF2	13 interacting genes: ABHD16A ASPH CREB3 LGALS2 LTB LTBR SLC30A2 TMEM237 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD
Entrez ID		7780	4049
HPRD ID		18057	01084
Ensembl ID		ENSG00000158014	ENSG00000226979
Uniprot IDs		Q9BRI3	P01374 Q5STV3
PDB IDs			1TNR 4MXV 4MXW
Enriched GO Terms of Interacting Partners?
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