LTA and LGALS2

Number of citations of the paper that reports this interaction (PubMedID 15129282)
52

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		LTA	LGALS2
Description		lymphotoxin alpha	galectin 2
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane	Cytoplasm
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding Galactoside Binding Carbohydrate Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Xenobiotic Stimulus Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Positive Regulation Of Apoptotic Process Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Etanercept	Beta-D-Glucose
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body shape index ( 34021172) Crohn's disease ( 21102463) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Kawasaki disease ( 33106546) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Malaria ( 31844061) Monocyte count ( 32888494) Neonatal lupus ( 20662065) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Tumor necrosis factor levels ( 32805626) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252)	Blood protein levels ( 30072576 29875488) Response to anti-depressant treatment in major depressive disorder ( 22041458)
Interacting Genes		13 interacting genes: ABHD16A ASPH CREB3 LGALS2 LTB LTBR SLC30A2 TMEM237 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD	7 interacting genes: APP IKBKG LTA NTAQ1 SDCBP SDCBP2 TUBA4A
Entrez ID		4049	3957
HPRD ID		01084	08859
Ensembl ID		ENSG00000226979	ENSG00000100079
Uniprot IDs		P01374 Q5STV3	P05162
PDB IDs		1TNR 4MXV 4MXW	1HLC 5DG1 5DG2 5EWS
Enriched GO Terms of Interacting Partners?
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